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    犬助孕素(孕酮)缺乏症 (Hypoluteoidism in bitches)
    犬助孕素(孕酮)缺乏症 (Hypoluteoidism in bitches)
  • 内排泄
  • 2019-07-08 14:06:09
  • 泉源: 
  • 助孕素缺乏症是母犬有身失败的缘由之一。

    择要

    助孕素缺乏症是母犬有身失败的缘由之一。诊断需求察看到非常低血清助孕素浓度,以及超音波验证存活的胎儿状况。医治办法是注射自然助孕素或口服分解的助孕激素,且必需在排卵后约60天中止医治以利幼犬的自觉性临盆。

    助孕素 (progesterone)

    助孕素亦被称为孕酮、黄体酮、孕甾酮、黄体甾酮、助孕激素、黄体素或助孕酮,其缩写为P4是一种内素性类固醇和孕激生性激素,也是在体内的次要孕激素,由雌性的卵巢排泄,但是雄性则是由肾上腺皮质排泄。在哺乳植物体内,助孕素之生分解就跟其他类固醇一样,是由孕烯醇酮分解;而孕烯醇酮又是从胆固醇转化而来。助孕素担任人类和别的物种的月经周期,有身和胚胎进程,此中助孕素所饰演之生理功用脚色在差别物种之中是类似的,比方滋养肥厚子宫内膜来让受精卵着床,亦也可以安慰乳房生长及阴道表皮细胞的繁衍,增加子宫肌层感觉性及膨胀,但是排泄周期和工夫是会因物种差别而差别。母犬于发情周期中,受促黄体素(luteinizing hormone, LH)诱导下,血液中助孕素含量随之上升且在排卵后降落,并在临盆前一天或当天降落至根底程度(图一)。

    诊断犬助孕素缺乏症

    助孕素缺乏症是由于黄体排泄的助孕素量缺乏,随后招致血清中助孕素浓度增加和怀胎失败。故诊断助孕素缺乏症可以藉由检测血液中助孕素,以及超音波察看腹中胎儿情况断定之。除了黄体非常外,母犬自身发作创伤或满身性疾病,或是胎儿罹患后天性疾病也能够会形成怀胎犬只其血清中助孕素浓度增加。但是,其他熏染性疾病比方布鲁氏菌,大肠杆菌、链球菌属、弓形虫病和犬疱疹病毒等熏染也会形成怀胎失败。现在针对血液中助孕素的侦测可以运用放射免疫剖析法(radioimmunoassay, RIA)、化学寒光免疫剖析法(chemiluminescent immunoassay, CLIA)和酵素联合免疫吸附剖析法(enzyme-linked immunosorbent assay, ELISA)。

    犬只助孕素缺乏症诊断方法:

    (1).不孕的病史

    (2).临床及妇科反省

    (3).3次延续有身都在LH顶峰后20天左右发作血中助孕素浓度降落。

    (4).赐与额定助孕速增补后,可以顺遂完成有身。

    犬助孕素缺乏症之医治与察看

    助孕素缺乏症的医治可以藉由施打自然助孕素或许是口服人工分解的助孕激素。血清助孕素浓度因增补剂会在最初一次注射后三天内增加;而在口服增补剂停药后一天内增加。此中需留意的是,人工分解的孕酮激素比方Regu-mate® 或 altrenogest无法被市售检测试剂中抗体所辨识,故难以监测投喂后犬只血液中孕酮浓度。假使施予母犬过多助孕素,使血液中高浓度助孕素维持工夫凌驾临盆日,能够会招致母犬无法天然临盆或是仔犬胎去世腹中。

    图一 犬发情周期贺尔蒙变革。

    参考文献

    1. Austad R, Lunde A, Sjaastad OV. Peripheral plasma levels of oestradiol 17beta and progesterone in the bitch during the oestrus cycle, in normal pregnancy and after dexamethasone treatment. J Reprod Fertil 1976; 46:129-136.

    2. Concannon PW. Reproductive cycles of the domestic bitch. Anim Reprod Sci 2011; 124:200-210.

    3. Concannon PW, Butler WR, Hansel W, et al. Parturition and lactation in the bitch: Serum progesterone, cortisol and prolactin. Biol Reprod 1978; 19:1113-1118.

    4. Concannon PW, McCann JP, Temple M. Biology and endocrinology of ovulation, pregnancy and parturition in the dog. J Rep Fert 1989; Suppl 39:3-25.

    5. England GCW, Verstegen JP. Prediction of parturition in the bitch using semi-quantitative ELISA measurement of plasma progesterone concentration. Vet Rec 1996; 139:496-497.

    6. Eilts BE. Pregnancy maintenance in the bitch using Regumate. In: Proceedings Annu Meet Soc Theriogenology 1992; 144-147.

    7. Gloria A, Contri A, Carluccio A, et al. Blood periovulatory progesterone quantification using different techniques in the dog. Anim Reprod Sci 2018; 192:179-184.

    8. Hadley JC. Total unconjugated estrogen and progesterone concentrations in peripheral blood during pregnancy in the dog. J Rep Fert 1975; 44:453-460.

    9. Johnston SD, Root MV. Serum progesterone timing of ovulation in the bitch. In: Proceedings Annu Meet Soc Theriogenology 1995; 195-203.

    10. Post K. Embryo and fetal loss in the canine: A review. Handbook of the Society for Theriogenology / American College of Theriogenologists. 1995.

    11. Nett TM, Akbar AM, Phemister RD, et al. Levels of luteinizing hormone, estradiol and progesterone in serum during the estrous cycle and pregnancy in the Beagle bitch. In: Proceedings Soc Exptl Biol Med 1975; 148:134-139.

    12. Smith MS, McDonald LE. Serum levels of luteinizing hormone and progesterone during the estrous cycle, pseudopregnancy and pregnancy in the dog. Endocrinology 1974; 94:404-412.

    13. Tsutsui T. Effects of ovariectomy and progesterone treatment on the maintenance of pregnancy in bitches. Jpn J Vet Sci 1983; 45:47-51.

    本文作者

    蔡铭原

    百卫植物临床查验实行室 蔡铭原 博士
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